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MOLECULAR CHAPERONES AND THE BIOSYNTHESIS OF ANTIGEN RECEPTORS

被引：67
作者：
MELNICK, J [1 ]
ARGON, Y [1 ]
机构：
[1] UNIV CHICAGO,DEPT PATHOL,CHICAGO,IL 60637
来源：
IMMUNOLOGY TODAY | 1995年 / 16卷 / 05期
关键词：
D O I：
10.1016/0167-5699(95)80167-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Oligomeric antigen receptors must fold and assemble in the endoplasmic reticulum (ER) before they can be expressed on the surface of lymphocytes. It is increasingly evident that these processes are facilitated by molecular chaperones. Here, Jeffrey Melnick and Yair Argon review the known ER chaperones, summarize their roles in the maturation of antigen receptors, and discuss how they may affect lymphocyte differentiation and function.
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页码：243 / 250
页数：8
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