STRUCTURAL-ANALYSIS BY NMR OF ANTITUMOR DRUG-DNA COMPLEXES - 9-AMINOANTHRACYCLINE (SM-5887)

被引：12

作者：

IGARASHI, J ^{[1
]}

SUNAGAWA, M ^{[1
]}

机构：

[1] SUMITOMO PHARMACEUT CO LTD,DEV RES LABS 1,KONOHANA KU,OSAKA 554,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 23期

关键词：

D O I：

10.1016/0960-894X(95)00505-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887-d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.

引用

页码：2923 / 2928

页数：6

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