PLASMODIUM-GALLINACEUM - INDUCTION OF MALE GAMETOCYTE EXFLAGELLATION BY PHOSPHODIESTERASE INHIBITORS

被引：29

作者：

MARTIN, SK

MILLER, LH

NIJHOUT, MM

CARTER, R

机构：

[1] Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda

来源：

EXPERIMENTAL PARASITOLOGY | 1978年 / 44卷 / 02期

关键词：

8-Bromo-cyclic adenosine monophosphate; 8-Hydroxy-cyclic adenosine monophosphate; Adenosine 3′:5′-monophosphate; Aedes aegypti; Caffeine; Chicken; Cyclic nucleotide; Dibutyryl cyclic adenosine monophosphate; Exflagellation; Gamete; Gametocyte; Malaria of birds; Mosquito; Parasitic protozoa; Phosphodiesterase inhibitor; Plasmodium gallinaceum; Squibb; 20009;

D O I：

10.1016/0014-4894(78)90104-2

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The phosphodiesterase inhibitors, Squibb 20009, caffeine, and 8-bromo-cyclic adenosine monophosphate (8-bromo-cAMP) are capable of stimulating gametogenesis, thus implicating cyclic nucleotides in the initiation of this process. Squibb 20009 and 8-bromo-cAMP stimulated gametogenesis at pH 8.0 but not at pH 7.4 whereas caffeine stimulated gametogenesis at pH 8.0 and 7.4. © 1978.

引用

页码：239 / 242

页数：4

共 8 条

[1]

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[5] GAMETE DEVELOPMENT IN MALARIA PARASITES - BICARBONATE-DEPENDENT STIMULATION BY PH INVITRO [J].

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CARTER, R .

PARASITOLOGY, 1978, 76 (FEB) :39-&

[6]

NIJHOUT MM, 1977, 5TH INT C PROT NEW Y

[7]

Simon L N, 1973, Adv Cyclic Nucleotide Res, V3, P225

[8] ADENOSINE-3',5'-MONOPHOSPHATE IN REPRODUCING AND DIFFERENTIATED TRYPANOSOMES [J].

STRICKLER, JE ;

PATTON, CL .

SCIENCE, 1975, 190 (4219) :1110-1112

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