DECREASE IN ACETAMINOPHEN TOXICITY IN MICE TREATED WITH METYRAPONE

被引：5

作者：

FOSSA, AA

HADLEY, WM

BORN, JL

机构：

[1] University of New Mexico, College of Pharmacy, Albuquerque

来源：

TOXICOLOGY LETTERS | 1979年 / 4卷 / 05期

关键词：

D O I：

10.1016/0378-4274(79)90048-1

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Metyrapone, an inhibitor of cytochrome P-450, was administered to mice to determine the effects on acetaminophen toxicity. Metyrapone increased the acetaminophen LD-50 by 30%. Hepatic glutathione depletion was significantly less in the metyrapone-treated mice while the time to maximum depletion was delayed. Histological studies showed a significant decrease in the hepatic necrosis in mice receiving metyrapone after acetaminophen compared to mice receiving acetaminophen alone. © 1979.

引用

页码：379 / 384

页数：6