Destination Therapy: Current Results and Future Promise

被引:28
作者
Lietz, Katherine [1 ]
Miller, Leslie W. [2 ]
机构
[1] Columbia Presbyterian Med Ctr, Ctr Adv Cardiac Care, PH12 Stem Rm 134,622 W 168th St, New York, NY 10032 USA
[2] Georgetown Univ, Washington Hosp Ctr, Cardiovasc Div, Washington, DC 20007 USA
关键词
ventricular assist devices; advanced heart failure;
D O I
10.1053/j.semtcvs.2008.08.004
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
The landmark Randomized Evaluation of Mechanical Assistance in the Treatment of Congestive Heart Failure (REMATCH) trial demonstrated that the implantation of left ventricular assist devices (LVADs) as an alternative to heart transplantation, or destination therapy (DT) is superior to any known medical therapy in patients with end-stage heart failure who are not eligible for transplantation. In this article, we review results of the first United States and European clinical trials of DT, including the REMATCH, the Investigation of the Non-Transplant Eligible Patients who are Inotrope Dependent (INTREPID), and the Clinical Utility Baseline Study (CUBS) trials, as well as the outcomes of the first DT implantations in the post-REMATCH era in the United States. The article summarizes the current state of knowledge and future directions in the field of permanent mechanical circulatory support therapy as an alternative to heart transplantation. © 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:225 / 233
页数:9
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