EFFECT OF PSYCHOTROPIC AGENTS ON A MODEL OF ABSENCE EPILEPSY IN RATS

被引:26
作者
FREY, HH
VOITS, M
机构
[1] Department of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, D-1000 Berlin 33
关键词
ABSENCE MODEL IN RATS; MORPHINE-LIKE ANALGESICS; AMPHETAMINE; ANTI-PARKINSON DRUGS; TRICYCLIC ANTIDEPRESSANTS; NMDA ANTAGONISTS; MEMANTINE;
D O I
10.1016/0028-3908(91)90086-Q
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of different groups of psychotropic agents on the spontaneous absence-like paroxysms in the ECoG of rats was studied in order to evaluate the specificity of the model for antiabsence drugs. Morphine-like analgesics increased the number of paroxysms, whereas this was depressed or the discharges were completely abolished by the following drugs: d-amphetamine, tricyclic antidepressants, centrally acting anticholinergics and L-DOPA, NMDA antagonists and memantine. Since the latter drugs have been reported to be effective in petit mal epilepsy, or the NMDA antagonists and memantine, have a potential anticonvulsant effect, the results are in favour of the usefulness of the model for antiabsence drugs.
引用
收藏
页码:651 / 656
页数:6
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