DUAL ROLE FOR CALCIUM IN THE CONTROL OF SPIKE DURATION IN RAT SUPRAOPTIC NEUROENDOCRINE CELLS

被引：23

作者：

KIRKPATRICK, K

BOURQUE, CW

机构：

[1] MONTREAL GEN HOSP, CTR RES NEUROSCI, 1650 CEDAR AVE, MONTREAL H3G 1A4, QUEBEC, CANADA

[2] MCGILL UNIV, MONTREAL H3A 2T5, QUEBEC, CANADA

来源：

NEUROSCIENCE LETTERS | 1991年 / 133卷 / 02期

关键词：

SUPRAOPTIC NUCLEUS; ACTION POTENTIAL; CA2+; NEUROENDOCRINE CELL; RAT;

D O I：

10.1016/0304-3940(91)90586-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Magnocellular neurosecretory cells (MNCs) display activity-dependent changes in spike duration to modulate Ca2+ influx both in their somata, and in their axon terminals in the neurohypophysis. This study reveals (i) that Ca2+ influx is required to mediate the expression of spike broadening, and (ii) that internal Ca2+ activates a delayed component of spike repolarization in MNCs of the rat supraoptic nucleus. This mechanism provides a rapid feedback control of spike-mediated Ca2+ influx in these neuroendocrine cells.

引用

页码：271 / 274

页数：4

共 18 条

[1] INTRACELLULAR CA2+ ACTIVATES A FAST VOLTAGE-SENSITIVE K+ CURRENT IN VERTEBRATE SYMPATHETIC NEURONS [J].