STUDIES ON THE MECHANISM OF DEACETOXY DEACETYLCEPHALOSPORIN-C SYNTHASE USING CYCLOPROPYL SUBSTITUTED CEPHALOSPORIN PROBES

被引：17

作者：

BALDWIN, JE ^{[1
]}

ADLINGTON, RM ^{[1
]}

CROUCH, NP ^{[1
]}

KEEPING, JW ^{[1
]}

LEPPARD, SW ^{[1
]}

PITLIK, J ^{[1
]}

SCHOFIELD, CJ ^{[1
]}

SOBEY, WJ ^{[1
]}

WOOD, ME ^{[1
]}

机构：

[1] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 11期

关键词：

D O I：

10.1039/c39910000768

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclopropyl substituted cephalosporin analogues were prepared and evaluated as substrates for the Fe(II)/alpha-ketoglutarate dependent oxygenase, DAOC-DAC synthase; the first example of catalytic product formation from a cyclopropyl ring cleavage pathway by an alpha-ketoglutarate dependent oxygenase is reported.

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收藏

页码：768 / 770

页数：3

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