FAMILY HISTORY AND RISK OF BREAST-CANCER

被引:49
作者
HOULSTON, RS
MCCARTER, E
PARBHOO, S
SCURR, JH
SLACK, J
机构
[1] UNIV LONDON,SCH MED,LONDON NW3 2QG,ENGLAND
[2] ROYAL FREE HOSP,DEPT SURG,LONDON NW3 2QG,ENGLAND
[3] UNIV COLL & MIDDLESEX HOSP SCH MED,DEPT SURG,LONDON W1N 8AA,ENGLAND
关键词
D O I
10.1136/jmg.29.3.154
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The risk of breast cancer in first degree relatives of patients with breast cancer can be derived from family history and is dependent upon the age at diagnosis in the index patient. For the relatives of index patients older than 55, the relative risk is 1.57, if less than 55 the relative risk is 2.29, and 3.85 if less than 45 (95% confidence limits 0.83 to 2.68, 1.18 to 4.01, and 1.67 to 3.85, respectively). First degree relatives of patients with bilateral breast cancer have a 6.43-fold increase in risk (95% confidence limits 1.32 to 18.77). The genetic contribution to overall lifetime liability to breast cancer in the relatives declines rapidly with increasing age of onset of breast cancer in the index patient from 37% at 20 years to 8% by 45 years. This information can be used in clinical practice for counselling and the establishment of screening programmes.
引用
收藏
页码:154 / 157
页数:4
相关论文
共 24 条
[1]  
ANDERSON DE, 1971, CANCER, V28, P1500, DOI 10.1002/1097-0142(197112)28:6<1500::AID-CNCR2820280623>3.0.CO
[2]  
2-D
[3]  
ANDERSON DE, 1974, CANCER, V34, P1090, DOI 10.1002/1097-0142(197410)34:4<1090::AID-CNCR2820340419>3.0.CO
[4]  
2-J
[5]  
[Anonymous], 1966, BIOMETR TABLES ST
[6]   RISK-FACTORS FOR BREAST-CANCER ACCORDING TO AGE AT DIAGNOSIS IN A FRENCH CASE CONTROL STUDY [J].
BOUCHARDY, C ;
LE, MG ;
HILL, C .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 1990, 43 (03) :267-275
[7]  
BRESLOW NE, 1987, STATISTICAL METHODS, pCH2
[8]  
CLAUS EB, 1991, AM J HUM GENET, V48, P232
[9]   BREAST-CANCER RISK ASSOCIATED WITH PROLIFERATIVE DISEASE, AGE AT 1ST BIRTH, AND A FAMILY HISTORY OF BREAST-CANCER [J].
DUPONT, WD ;
PAGE, DL .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1987, 125 (05) :769-779
[10]   WHAT ARE THE PSYCHOLOGICAL-FACTORS INFLUENCING ATTENDANCE, NONATTENDANCE AND RE-ATTENDANCE AT A BREAST SCREENING CENTER [J].
FALLOWFIELD, LJ ;
RODWAY, A ;
BAUM, M .
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1990, 83 (09) :547-551