DIETARY MODULATION OF DNA DAMAGE IN HUMAN

被引：74

作者：

SIMIC, MG

BERGTOLD, DS

机构：

[1] National Institute of Standards and Technology, Gaithersburg

来源：

MUTATION RESEARCH | 1991年 / 250卷 / 1-2期

关键词：

AGING; ANTIOXIDANTS; BIOMARKERS; CALORIC RESTRICTION; DIET; DNA DAMAGE; HYDROXYL RADICAL; OXIDATIVE PROCESSES; PREVENTION OF DEGENERATIVE DISEASES; REACTIVE OXYGEN SPECIES;

D O I：

10.1016/0027-5107(91)90158-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Manipulation of human diet can modulate urinary biomarkers of oxidative DNA base damage (UBODBD), reflecting changes in levels of DNA damage. When dietary composition is maintained but caloric intake is decreased (caloric restriction), UBODBD excretion is suppressed. At isocaloric dietary intake the level of damage depends on diet composition. For diets consisting of foods containing carbohydrates, proteins, and fats but lacking fruits and vegetables, the level of damage is higher than for diets including fruits and vegetables, which are rich in natural antioxidants. Assay of urinary biomarkers is suggested as a potential test for quantitative assessment of the carcinogenic or anticarcinogenic properties of foods, food components, and diets and for individual responses to nutritional regimens.

引用

页码：17 / 24

页数：8

共 41 条

[1] TOO MANY RODENT CARCINOGENS - MITOGENESIS INCREASES MUTAGENESIS [J].