STUDIES ON THE ANTIMICROBIAL ACTIVITY OF NIGELLA-SATIVA SEED (BLACK CUMIN)

被引：230

作者：

HANAFY, MSM

HATEM, ME

机构：

[1] UNIV CAIRO,FAC VET MED,DEPT PHARMACOL,GIZA,EGYPT

[2] UNIV CAIRO,FAC VET MED,DEPT MICROBIOL,GIZA,EGYPT

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1991年 / 34卷 / 2-3期

关键词：

NIGELLA-SATIVA; ANTIMICROBIAL; ANTIBIOTICS; BACTERIAL INFECTION; FOOD POISONING;

D O I：

10.1016/0378-8741(91)90047-H

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Filter paper discs impregnanted with the diethyl ether extract of Nigella sativa seeds (25-400-mu-g extract/disc) caused concentration-dependent inhibition of Gram-positive bacteria represented by Staphylococcus aureus, Gram-negative bacteria represented by Pseudomonas aeruginosa and Escherichia coli (but not Salmonella typhimurium) and a pathogenic yeast Candida albicans. The extract showed antibacterial synergism with streptomycin and gentamicin and showed additive antibacterial action with spectinomycin, erythromycin, tobramycin, doxycycline, chloramphenicol, nalidixic acid, ampicillin, lincomycin and sulphamethoxyzole-trimethoprim combination. The extract successfully eradicated a non-fatal subcutaneous staphylococcal infection in mice when injected at the site of infection.

引用

页码：275 / 278

页数：4