LOCALIZATION OF HEAT-SHOCK PROTEIN IN ORBITAL TISSUE FROM PATIENTS WITH GRAVES OPHTHALMOPATHY USING IN-SITU HYBRIDIZATION

被引：4

作者：

TANAKA, K ^{[1
]}

HIROMATSU, Y ^{[1
]}

SATO, M ^{[1
]}

INOUE, Y ^{[1
]}

NONAKA, K ^{[1
]}

机构：

[1] OLYMPIA MED CLIN,DIV EYE,SHIBUYA KU,TOKYO,TOKYO 150,JAPAN

来源：

LIFE SCIENCES | 1994年 / 54卷 / 05期

关键词：

D O I：

10.1016/0024-3205(94)00791-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the cellular localization of heat shock protein 70 (HSP70) synthesis in human orbital tissue from patients with Graves' ophthalmopathy(GO) before and after immunosuppressive therapy. Synthesis was detected using in situ hybridization techniques. In a specimen from a GO patient in active phase, strong expression of HSP70 mRNA was detected in infiltrating lymphocytes as well as in fibroblasts. HSP70 mRNA was also detected in orbital tissue fibroblasts from GO patients following treatment, but notin control specimens. HSP70 expression in the orbital tissue of GO patients may be important in mediation of the immune process.

引用

页码：355 / 359

页数：5

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