PROSTATE-SPECIFIC ANTIGEN DECLINE AFTER CASODEX WITHDRAWAL - EVIDENCE FOR AN ANTIANDROGEN WITHDRAWAL SYNDROME

被引：125

作者：

SMALL, EJ

CARROLL, PR

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT UROL,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,MT ZION MED CTR,GENITOURINARY ONCOL SERV,SAN FRANCISCO,CA 94143

来源：

UROLOGY | 1994年 / 43卷 / 03期

关键词：

D O I：

10.1016/0090-4295(94)90092-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the relationship between antiandrogen withdrawal and change in prostate-specific antigen (PSA) when the antiandrogen in question is other than flutamide. Methods. Presented is a case of a patient in whom the antiandrogen casodex was discontinued after clinical progression despite combined androgen blockade. Results. A transient decline in serum PSA was observed after casodex withdrawal. Conclusions. The relationship between antiandrogen withdrawal and a change in PSA may be a general phenomenon, not unique to flutamide.

引用

页码：408 / 410

页数：3

共 6 条

[1] ORCHIECTOMY AND NILUTAMIDE OR PLACEBO AS TREATMENT OF METASTATIC PROSTATIC-CANCER IN A MULTINATIONAL DOUBLE-BLIND RANDOMIZED TRIAL [J].