ADENOSINE-ANALOGS MODULATE THE INCIDENCE OF SLEEP APNEAS IN RATS

被引：28

作者：

MONTI, D ^{[1
]}

CARLEY, DW ^{[1
]}

RADULOVACKI, M ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL MED,DEPT MED,CHICAGO,IL 60612

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 51卷 / 01期

关键词：

N-6-PHENYLISOPROPYLADENOSINE (L-PIA); CGS21680; SLEEP APNEAS; RATS; ADENOSINE A(1) RECEPTORS; ADENOSINE A(2) RECEPTORS; CONTROL OF RESPIRATION; CAROTID BODIES; CHEMORECEPTORS;

D O I：

10.1016/0091-3057(94)00395-Y

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of adenosine A(1) and A(2) agonists on spontaneous central sleep apneas in rats have been examined by simultaneously monitoring sleep and respiration in freely moving unanesthetized animals. Intraperitoneal administration of 1.0 mg/kg of the A(1) receptor agonist R(-)N-6-L-(2-phenyl-isopropyl)adenosine (L-PIA) and 150 and 300 mu g/kg of 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamido-adenosine hydrochloride (CGS 21680), a selective A(2) agonist, decreased the apnea index (AI) during sleep. Within a sleep period, AI increased over time in both control and drug-treated animals. For both agonists, doses effective in reducing AI also significantly reduced sleep efficiency.

引用

页码：125 / 131

页数：7

共 37 条

[1] CARDIOVASCULAR AND RESPIRATORY EFFECTS OF ADENOSINE IN CONSCIOUS MAN - EVIDENCE FOR CHEMORECEPTOR ACTIVATION [J].