THE ANTIINFLAMMATORY ACTIVITY OF TOPICALLY APPLIED NOVEL CALCIUM-CHANNEL ANTAGONISTS

被引：11

作者：

DEVRIES, GW ^{[1
]}

MCLAUGHLIN, A ^{[1
]}

WENZEL, MB ^{[1
]}

PEREZ, J ^{[1
]}

HARCOURT, D ^{[1
]}

LEE, G ^{[1
]}

GARST, M ^{[1
]}

WHEELER, LA ^{[1
]}

机构：

[1] ALLERGAN PHARMACEUT INC,DEPT CHEM SCI,IRVINE,CA 92715

来源：

INFLAMMATION | 1995年 / 19卷 / 02期

关键词：

D O I：

10.1007/BF01534466

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The antiinflammatory activities of two novel calcium-channel antagonists, AGN 190742 and AGN 190744, were evaluated in murine models of cutaneous inflammation. These 2(5H)-furanone ring compounds block both depolarization-dependent Ca2+ entry and receptor-mediated responses in GH3 cells. Topical application of AGN 190742 or AGN 190744 inhibits neutrophil infiltration and epidermal hyperplasia induced by repeated treatment of mouse skin with phorbol ester. AGN 190744 also is active in an arachidonic acid model of acute inflammation. These data suggest that topical application of calcium-channel antagonists can inhibit cutaneous inflammatory responses and that AGN 190742 and/or AGN 190744 may serve as useful pharmacological probes for examining these responses in vivo.

引用

页码：261 / 275

页数：15

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