INTERINDIVIDUAL VARIATION IN HALF-LIFE OF INFUSED RECOMBINANT FACTOR-VIII IS RELATED TO PRE-INFUSION VON-WILLEBRAND-FACTOR ANTIGEN LEVELS

被引：96

作者：

FIJNVANDRAAT, K ^{[1
]}

PETERS, M ^{[1
]}

TENCATE, JW ^{[1
]}

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,CTR HAEMOSTASIS THROMBOSIS ATHEROSCLEROSIS & INFL,1100 DE AMSTERDAM,NETHERLANDS

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 91卷 / 02期

关键词：

FACTOR VIII; HEMOPHILIA A; VON WILLEBRAND FACTOR; PHARMACOKINETICS; RECOMBINANT;

D O I：

10.1111/j.1365-2141.1995.tb05325.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In an attempt to explain the substantial interindividual variability in half-life of infused factor VIII (FVIII) among haemophilia A patients, we studied the correlation of pre-infusion von Willebrand factor antigen (vWFAg) levels and the half-life of a recombinant-DNA-derived FVIII (r-VIII SQ, Pharmacia, Sweden). Intra-individual variation in half-life was small (range of variation 0-2.1 h) in 12 severely affected haemophiliacs who received two doses of FVIII concentrate. In contrast, inter-individual variation in half-life was large (range of half-lives 6-28.8 h). A strong correlation between half-life and pre-infusion vWFAg levels was present (r = 0.87, P = 0.0003). We conclude that the half-life of infused recombinant FVIII is related to preinfusion vWFAg levels in severely affected haemophilia A patients.

引用

页码：474 / 476

页数：3

共 10 条

[1]

CARLSSON N, 1993, EUR J HAEMATOL, V51, P247

[2] PATIENTS WITH SEVERE VON-WILLEBRAND DISEASE ARE INSENSITIVE TO THE RELEASING EFFECT OF DDAVP - EVIDENCE THAT THE DDAVP-INDUCED INCREASE IN PLASMA FACTOR-VIII IS NOT SECONDARY TO THE INCREASE IN PLASMA VON-WILLEBRAND-FACTOR [J].