STAPHYLOCOCCAL-ENTEROTOXIN-B AFFECTS IN-VITRO IGE SYNTHESIS, INTERFERON-GAMMA, INTERLEUKIN-4 AND INTERLEUKIN-5 PRODUCTION IN ATOPIC ECZEMA

被引：56

作者：

NEUBER, K ^{[1
]}

STEINRUCKE, K ^{[1
]}

RING, J ^{[1
]}

机构：

[1] UNIV HAMBURG,HOSP EPPENDORF,DEPT DERMATOL & ALLERGOL,D-20246 HAMBURG,GERMANY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCAL ENTEROTOXIN B; CYTOKINES; IGE; ATOPIC ECZEMA;

D O I：

10.1159/000236970

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Peripheral blood mononuclear cells from patients with atopic eczema (AE) stimulated with the 'superantigen' Staphylococcus enterotoxin B (SEE) secreted significantly more interleukin (IL)-4 and IL-5 as well as IgE, and markedly less interferon-gamma than those from healthy controls. Our results support the assumption that SEE produced by S. aureus colonizing the skin of patients with AE may induce expansion of IL-4- and IL-5-producing Th2 clones, leading to increased IgE synthesis and eosinophil activation.

引用

页码：179 / 182

页数：4