PHARMACEUTICAL HETEROGENEOUS SYSTEMS .3. INHIBITION OF STEARATE LUBRICANT INDUCED DEGRADATION OF ASPIRIN BY USE OF CERTAIN ORGANIC ACIDS

被引：14

作者：

ZOGLIO, MA

MAULDING, HV

HALLER, RM

BRIGGEN, S

机构：

[1] Pharmacy Research and Development Departments, Hanover, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 11期

关键词：

Aspirin degradation; stearate‐induced—inhibition; Heterogeneous systems—pharmaceutical; Moisture effect—aspirin degradation; Organic acids effect—stearate degradation; aspirin; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600571111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The acceleration of aspirin degradation in capsule formulations where an alkali stearate is employed as a lubricant can be inhibited by the inclusion of malic, hexamic, or maleic acid. The acids when included at a level of 20 percent by weight of the complete mixture achieve a level of inhibition at which it could be said that the preparations are stable with respect to salicylic acid content. The mechanisms operative in these systems and the factors contributing to successful inhibition are described. Moisture content of the capsule mix and in the gelatin capsule shell is studied in regard to effects on the stability of aspirin and the dissolution rate of aspirin from the capsule formulations considered. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1877 / &

共 5 条

[1] THE HYDROLYSIS OF ASPIRIN - A DETERMINATION OF THE THERMODYNAMIC DISSOCIATION CONSTANT AND A STUDY OF THE REACTION KINETICS BY ULTRA-VIOLET SPECTROPHOTOMETRY [J].