PRODUCTION OF TUMORS IN INTESTINES OF MICE BY 1,2-DIMETHYLHYDRAZINE

被引：74

作者：

WIEBECKE, B

LOHRS, U

GIMMY, J

EDER, M

机构：

来源：

ZEITSCHRIFT FUR DIE GESAMTE EXPERIMENTELLE MEDIZIN | 1969年 / 149卷 / 03期

关键词：

Benzpyrene; Carcinoma; Dimethylbenzanthracene; Dimethylhydrazine; Intestine; Polyp;

D O I：

10.1007/BF02044483

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Whereas cancerification of the intestinal mucosa cannot be produced by rectal instillation of Dimethylbenzanthracene and Benzpyrene, adenomatous polyps and adenocarcinomas of the intestines develop after subcutaneous injection of 1,2-Dimethylhydrazine not only in rats but also in mice. With the application of relatively low weekly doses the tumors were limited to the large intestine and only mucosal metaplasias appeared in the ileum. © 1969 Springer-Verlag.

引用

页码：277 / &