MODIFIED USP ASSAY FOR SIMULTANEOUS DETERMINATION OF ASPIRIN AND NON-ASPIRIN SALICYLATES IN ASPIRIN AND BUFFERED ASPIRIN TABLETS

Modified USP procedures are described for the simultaneous determination of nonaspirin salicylates and aspirin in aspirin and buffered aspirin tablets. The existing USP procedures are not stability indicating for intact aspirin when significant levels of nonaspirin salicylates are present, as is often the case in short‐term, high temperature stability programs. The modified procedures yield considerably shorter analysis times and stability‐indicating assays for intact aspirin without the need for sophisticated equipment other than that presently required by USP XIX. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company