THE EFFECT OF QUERCETIN ON CELL-CYCLE PROGRESSION AND GROWTH OF HUMAN GASTRIC-CANCER CELLS

被引：289

作者：

YOSHIDA, M

SAKAI, T

HOSOKAWA, N

MARUI, N

MATSUMOTO, K

FUJIOKA, A

NISHINO, H

AOIKE, A

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT PREVENT MED,KAMIKYO KU,KYOTO 602,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KAMIKYO KU,KYOTO 602,JAPAN

来源：

FEBS LETTERS | 1990年 / 260卷 / 01期

关键词：

(Human gastric cancer cell); Cell cycle; Quercetin;

D O I：

10.1016/0014-5793(90)80053-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quercetin, a flavonoid, is found in many plants, including edible fruits and vegetables. We examined the effects on cell growth of human malignant cells derived from the gastrointestinal tract and on cell cycle progression. Quercetin markedly inhibited the growth of human gastric cancer cells and the IC50 value was 32-55 μM. DNA synthesis was suppressed to 14% of the control level by the treatment with 70 μM quercetin for 2 days. Furthermore, quercetin blocked cell progression from the G1 to the S phase. © 1990.

引用

页码：10 / 13

页数：4

共 25 条

[1]

AKAGI T, 1976, ACTA MED OKAYAMA, V30, P215

[2]

AKIYAMA S, 1988, JPN J SURG, V18, P447

[3] MUTAGENIC ACTIVITY OF QUERCETIN AND RELATED COMPOUNDS [J].

BJELDANES, LF ;

CHANG, GW .

SCIENCE, 1977, 197 (4303) :577-578

[4] MUTAGENICITY OF PLANT FLAVONOLS IN THE SALMONELLA-MAMMALIAN MICROSOME TEST - ACTIVATION OF FLAVONOL GLYCOSIDES BY MIXED GLYCOSIDASES FROM RAT CECAL BACTERIA AND OTHER SOURCES [J].

BROWN, JP ;

DIETRICH, PS .

MUTATION RESEARCH, 1979, 66 (03) :223-240

[5] A REVIEW OF THE GENETIC-EFFECTS OF NATURALLY-OCCURRING FLAVONOIDS, ANTHRAQUINONES AND RELATED-COMPOUNDS [J].

BROWN, JP .

MUTATION RESEARCH, 1980, 75 (03) :243-277

[6]

GRAZIANI Y, 1979, BIOCHEM PHARMACOL, V28, P297

[7] CARCINOGENICITY EXAMINATION OF QUERCETIN AND RUTIN IN ACI RATS [J].

HIRONO, I ;

UENO, I ;

HOSAKA, S ;

TAKANASHI, H ;

MATSUSHIMA, T ;

SUGIMURA, T ;

NATORI, S .

CANCER LETTERS, 1981, 13 (01) :15-21

[8]

Hojo H., 1997, NIIGATA IGAKKAI ZASS, V91, P737

[9]

HOSAKA S, 1981, GANN, V72, P327

[10]

KATO K, 1984, Journal of Toxicological Sciences, V9, P319

← 1 2 3 →