MOLECULAR CHARACTERIZATION OF THE BORNA DISEASE AGENT

被引：62

作者：

DELATORRE, JC

CARBONE, KM

LIPKIN, WI

机构：

[1] UNIV CALIF IRVINE,DEPT NEUROL,IRVINE,CA 92717

[2] UNIV CALIF IRVINE,DEPT ANAT & NEUROBIOL,IRVINE,CA 92717

[3] SCRIPPS CLIN & RES FDN,RES INST,DEPT NEUROPHARMACOL,LA JOLLA,CA 92037

[4] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205

来源：

VIROLOGY | 1990年 / 179卷 / 02期

关键词：

D O I：

10.1016/0042-6822(90)90154-J

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Borna disease (BD) is a neurologic syndrome characterized by profound disturbances in behavior and the accumulation of specific antigens in limbic system neurons. The potency of brain homogenates from animals with BD to cause disease in normal animals is reduced by exposure to detergents. We have recently described isolation and characterization of clones derived from the BD agent. Here we present evidence that suggests that the BD agent is a negativesense, single-strand RNA virus. The 8.5-kb genome of this virus appears to be associated with nuclei and encodes two major RNA transcripts of 2.1 and 0.8 kb. © 1990.

引用

页码：853 / 856

页数：4

共 22 条

[1]

AMSTERDAM JD, 1985, ARCH GEN PSYCHIAT, V42, P1093

[2]

AVIV H, 1972, J MOL BIOL, V134, P743

[3]

BODE L, 1988, LANCET, V2, P689

[4] PATHOGENESIS OF BORNA DISEASE IN RATS - EVIDENCE THAT INTRAAXONAL SPREAD IS THE MAJOR ROUTE FOR VIRUS DISSEMINATION AND THE DETERMINANT FOR DISEASE INCUBATION [J].