HUMAN RECOMBINANT ACTIVIN-A INHIBITS PROLIFERATION OF HUMAN FETAL ADRENAL-CELLS INVITRO

被引：59

作者：

SPENCER, SJ ^{[1
]}

RABINOVICI, J ^{[1
]}

JAFFE, RB ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO, CTR REPROD ENDOCRINOL, DEPT OBSTET GYNECOL & REPROD SCI, SAN FRANCISCO, CA 94143 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1990年 / 71卷 / 06期

关键词：

D O I：

10.1210/jcem-71-6-1678

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activins and inhibins are dimeric peptides which are structurally and functionally related to transforming growth factor-β (TGF-β). The mRNA for the activin and inhibin subunits is expressed in the adrenal gland. Because members of the TGF-P superfamily have effects on mitogenesis, we examined the effect of recombinant human activin-A(rh-activin-A) on proliferation ofmidgestation human fetal adrenal cells in vitro. Dose-dependent growth inhibition by rh-activin-A was obtained, with an ED50 of 1 ng/ml. Rh-activin-A inhibited basal and epidermal growth factor (EGF)-stimulated fetal zone cell proliferation, but did not alter basic fibroblast growth factor (bFGF)-stimulated growth. TGF-β combined with rh-activin-A demonstrated additive inhibition of fetal adrenal growth. These findings suggest a potential autocrine or paracrine role for activin-A in modulating the growth and/or subsequent involution of the human fetal adrenal gland. © 1990 by The Endocrine Society.

引用

页码：1678 / 1680

页数：3

共 20 条

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