BIOLOGICAL-ACTIVITY OF METAL-COMPLEXES .1. INTERACTION OF PT(II), PD(II) AND RH(I) COMPLEXES WITH ESCHERICHIA-COLI STRAINS AND WITH MICE LS FIBROBLASTS INVITRO

被引：9

作者：

ARESTA, M ^{[1
]}

GIORDANO, D ^{[1
]}

INGROSSO, A ^{[1
]}

RICCARDI, S ^{[1
]}

SINIGAGLIA, E ^{[1
]}

机构：

[1] UNIV BARI, IST PATOL GEN, CATTEDRA 2, I-70124 BARI, ITALY

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 28卷 / 01期

关键词：

D O I：

10.1016/0009-2797(79)90114-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of a number of Pt(II), Pd(II) and Rh(I) complexes [cis-diamminedichloroplatinum(II), cis-dichloro(N,N-diallylaniline)platinum(II), [O-vinylphenyl] [O-(.alpha.,.beta.-dibromoethyl)phenyl]platinum(II), benzothiazole-chloro(cis,cis-1,5-cyclooctadiene)rhodium (I), dichloro(N,N,N'',N-tetraalylethylendiammine)palladium(II)] [all potential antineoplastic drugs] against cultures of Escherichia coli (strains B, H10178, uvra-, recA-) and cultures of mice LS fibroblasts were tested. Most of the compounds showed higher cytotoxic activity than cis-diamminedichloroplatinum(II), the compound at present on clinical trial as [a human] antitumor drug. A new model of active compound is proposed.

引用

页码：61 / 70

页数：10

共 26 条

[1] ANTITUMOUR AGENTS SYNTHESIZED FROM K2PTCL4 AND POLYMERIC OR CYCLIC PHOSPHAZENES [J].