PERSISTENCE OF VARIOUS POLYCHLORINATED DIBENZO-PARA-DIOXINS AND DIBENZOFURANS (PCDDS AND PCDFS) IN HEPATIC AND ADIPOSE-TISSUE OF MARMOSET MONKEYS

被引:37
作者
NEUBERT, D [1 ]
WIESMULLER, T [1 ]
ABRAHAM, K [1 ]
KROWKE, R [1 ]
HAGENMAIER, H [1 ]
机构
[1] UNIV TUBINGEN,INST ORGAN CHEM,W-7400 TUBINGEN 1,GERMANY
关键词
Elimination; Half-life; Marmoset monkeys (Callithrix jacchus); Polychlorinated dibenzo-p-dioxins (PCDDs); Polychlorinated dibenzofurans (PCDFs); Tissue distribution; Toxicokinetics;
D O I
10.1007/BF01977624
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
A defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) was subcutaneously administered to marmoset monkeys (Callithrix jacchus). Tissue concentrations in hepatic and adipose tissue were measured at different times after treatment (1-28 weeks). One week after application high concentrations could be detected for the 2,3,7,8-substituted congeners only. The percent of the administered dose in whole liver differed for the various 2,3,7,8-substituted congeners, ranging from 24.5±4.5% for 2,3,7,8-TCDD to 74.1±4.9% for 2,3,4,6,7,8-H6CDF. Therefore, the concentration ratio (liver/adipose tissue) was also very different, ranging from about 1 (2,3,7,8-T4CDD or 2,3,7,8-T4CDF) to >10 in the case of some higher chlorinated PCDDs and PCDFs. Half-lives of PCDDs and PCDFs were very different for the various 2,3,7,8-substituted congeners. For the most toxic compound (2,3,7,8-T4CDD) a t/2 of about 8 weeks in hepatic tissue and about 11 weeks in adipose tissue was found when calculated from data obtained later than 6 weeks after injection. For 2,3,7,8-T4CDD and 1,2,3,7,8-P5CDD the decreases in hepatic concentrations were much faster during the first 6 weeks after administration (t/2 of 4 weeks). This was apparently due to redistribution phenomena. Half-life increased with increasing degrees of chlorination. In some cases (e.g. OCDD, OCDF) no significant decrease in tissue concentrations could be observed after 28 weeks. The shortest t/2 was determined for 2,3,7,8-T4CDF: shorter than 6 days in hepatic tissue and about 10 days in adipose tissue. Calculation of the body burden of the non-2,3,7,8 -substituted PCDDs/PCDFs 1 week after injection revealed that all groups of isomers were present at less than 5%. Consequences of these findings for the use of TCDD-toxic-equivalency factors are discussed and a change in strategy is suggested. © 1990 Springer-Verlag.
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页码:431 / 442
页数:12
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