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CYCLIN-D AND ONCOGENESIS

被引：225
作者：
MOTOKURA, T
ARNOLD, A
机构：
[1] MASSACHUSETTS GEN HOSP, BOSTON, MA 02114 USA
[2] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1993年 / 3卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0959-437X(05)80334-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.
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页码：5 / 10
页数：6
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