SERUM CONCENTRATIONS OF TUMOR-NECROSIS-FACTOR-ALPHA DURING CHEMOTHERAPY-INDUCED LEUKOPENIA IN PATIENTS WITH ACUTE-LEUKEMIA AND BACTERIAL-INFECTIONS

被引：15

作者：

BRUSERUD, O

BERGHEIM, J

SHAMMAS, FV

NESTHUS, I

机构：

[1] Division for Haematology, Medical Department B, Haukeland University Hospital, Bergen

来源：

LEUKEMIA RESEARCH | 1994年 / 18卷 / 06期

关键词：

TUMOR NECROSIS FACTOR-ALPHA; ACUTE LEUKEMIA; LEUKOPENIA; BACTERIAL INFECTIONS;

D O I：

10.1016/0145-2126(94)90077-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Serum concentrations of tumour necrosis factor-alpha (TNF-alpha) increase during septicaemia in previously healthy individuals. To investigate whether a similar increase in TNF-alpha can be seen in severely immunocompromised patients with acute leukaemia and chemotherapy-induced leukopenia, serum TNF-alpha was analysed in leukopenic patients with bacterial infections. Pretherapy serum levels of TNF-alpha were decreased in leukaemia patients compared with healthy controls, and serum TNF-alpha levels showed a further decrease when patients developed chemotherapy-induced leukopenia. When leukopenic patients developed bacterial infections, serum concentrations of TNF-alpha increased. Serum levels of TNF-alpha decreased when clinical signs of infection resolved during antibiotic therapy, but an increase occurred later in parallel with haematopoietic reconstitution.

引用

页码：415 / 421

页数：7

共 15 条

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