4TH ISOFORM OF PREPROTACHYKININ MESSENGER-RNA ENCODING FOR SUBSTANCE-P IN THE RAT INTESTINE

被引：24

作者：

KHAN, I

COLLINS, SM

机构：

[1] Department of Medicine, Health Science Centre, McMaster University, Hamilton, ON

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three different isoforms of preprotachykinin mRNA (PPT mRNA) encode for substance P and related neuropeptides (1). Here we report a fourth isoform of PPT mRNA which is generated by alternative exclusion of exon-4 and exon-6 from the PPT mRNA. It was present mainly in ileal smooth muscle and mucosa, colon, heart and brain and low level of this mRNA was detected in the jejunal smooth muscle and mucosa. This was not detected in the kidney or uterus. The level of this PPT mRNA was enhanced significantly by 60% during colitis in rat induced by trinitro benzene sulphonic acid. (C) 1994 Academic Press, Inc.

引用

页码：796 / 802

页数：7

共 22 条

[1]

BEINFELD MC, 1989, J BIOL CHEM, V264, P4440

[2]

CARTER MS, 1990, J NEUROSCI, V10, P2203

[3] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].