DIFFERENCES IN BRAIN 5-HT TRANSPORTER DISSOCIATION RATES AMONG ANIMAL SPECIES

被引：14

作者：

ERREBOE, I ^{[1
]}

PLENGE, P ^{[1
]}

MELLERUP, ET ^{[1
]}

机构：

[1] UNIV COPENHAGEN,RIGSHOSP 6102,DEPT PHARMACOL,NEUROPSYCHIAT LAB,DK-2100 COPENHAGEN 0,DENMARK

来源：

PHARMACOLOGY & TOXICOLOGY | 1995年 / 76卷 / 06期

关键词：

D O I：

10.1111/j.1600-0773.1995.tb00165.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The potential of using receptor-ligand dissociation rates as a model for investigating molecular changes in receptors was tested using the dissociation of[H-3]citalopram, [H-3]paroxetine and [H-3]imipramine from the brain 5-HT transporter of four different species (mouse, rat, pig and man). Since the dissociation rates of each of the three ligands differed in most of the species investigated, receptor-ligand dissociation rate constants would seem to be a sensitive measure of receptor conformation. The model could be useful in the search of structural variation in receptors whether attributable to genetic factors or to posttranslational modification.

引用

页码：376 / 379

页数：4

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