EVIDENCE AGAINST OBLIGATORY FORMATION OF AN ACYL ENZYME INTERMEDIATE IN ALPHA-CHYMOTRYPSIN CATALYZED REACTIONS OF AMIDES

被引：24

作者：

EPAND, RM

机构：

[1] Instituto de Investigaciones Bioquímicas Fundsción Compomar

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 37卷 / 02期

关键词：

D O I：

10.1016/0006-291X(69)90736-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relative rates of chymotrypsin catalyzed reactions with water and with glycinamids differ for benzoyl-L-tyrosine ethyl ester and benzoyl-L-tyrosine glycinamide. These results indicate that a common benzoyl-L-tyrosine-chymotrypsin intermediate is not formed from both substrates. © 1969.

引用

页码：313 / &

共 17 条

[1] IDENTITY OF RATES OF DEACYLATION OF NONIONIC ACYL-ALPHA-CHYMOTRYPSINS + ACYL-TRYPSINS
BENDER, ML
KEZDY, FJ
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[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (23) : 5330 - &
[2] MECHANISM OF ACTION OF PROTEOLYTIC ENZYMES
BENDER, ML
KEZDY, FJ
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1965, 34 : 49 - &
[3] KINETICS OF ALPHA-CHYMOTRYPSIN REACTIONS IN PRESENCE OF ADDED NUCLEOPHILES
BENDER, ML
GUNTER, CR
KEZDY, FJ
CLEMENT, GE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (18) : 3697 - &
[4] CAPLOW M, 1964, J BIOL CHEM, V239, P1640
[5] CAPLOW M, 1963, J BIOL CHEM, V238, P3140
[6] SEPARATION OF PROTEOLYTIC AND ESTERASIC ACTIVITIES OF TRYPSIN BY REVERSIBLE STRUCTURAL MODIFICATIONS
COLETTIPREVIERO, MA
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[J]. JOURNAL OF MOLECULAR BIOLOGY, 1969, 39 (03) : 493 - +
[7] DOBRY A, 1952, J BIOL CHEM, V195, P149
[8] EPAND RM, 1963, J BIOL CHEM, V238, P1718
[9] EPAND RM, 1963, J BIOL CHEM, V239, P3138
[10] FOSTER RJ, 1961, J BIOL CHEM, V236, P2461

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