INSERTION OF THE FRAGILE 2'-DEOXYRIBOSYLUREA RESIDUE INTO OLIGODEOXYNUCLEOTIDES

被引：15

作者：

GUY, A

AHMAD, S

TEOULE, R

机构：

[1] Laboratoires de Chimie, Département de Recherche Fondamentale Centre d'Etudes Nucléaires, 38041 Grenoble Cedex

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(00)97947-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deoxyribosylurea is an alkali sensitive DNA defect induced by the action of ionizing radiation. Oligonucleotides bearing this residue were synthesized using 5′-O-(4-methoxytrilyl)-2′-deoxyribosylurea-3′-O-(2-cyanoethyl-N,N'-diisopropyl) phosphoramidite and PAC protected deoxynucleoside phosphoramidites. © 1990.

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页码：5745 / 5748

页数：4

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