ANTINEOPLASTIC AGENTS .249. ISOLATION AND STRUCTURE OF THE MARINE SPONGE CELL-GROWTH INHIBITORY CYCLIC PEPTIDE PHAKELLISTATIN 1

被引：83

作者：

PETTIT, GR

CICHACZ, Z

BARKOCZY, J

DORSAZ, AC

HERALD, DL

WILLIAMS, MD

DOUBEK, DL

SCHMIDT, JM

TACKETT, LP

BRUNE, DC

CERNY, RL

HOOPER, JNA

BAKUS, GJ

机构：

[1] ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287

[2] UNIV NEBRASKA,DEPT CHEM,MIDWEST CTR MASS SPECTRMETRY,LINCOLN,NE 68588

[3] QUEENSLAND MUSEUM,BRISBANE,QLD 4101,AUSTRALIA

[4] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 02期

关键词：

D O I：

10.1021/np50092a011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cell growth inhibitory (P-388 murine leukemia ED50 7.5 mug/ml) cycloheptapeptide designated phakellistatin 1 was isolated from two Indo-Pacific sponges, Phakellia costata and Stylotella aurantium. Structural elucidation was accomplished utilizing high field nmr, amino acid analyses, and mass spectral techniques (fab, tandem ms/ms), followed by chiral gas chromatographic procedures for absolute configuration assignments (all S-amino acid units). By these methods phakellistatin 1 [1] was found to be cyclo (Pro-Ile-Pro-Ile-Phe-Pro-Tyr), and this assignment was finally confirmed by an X-ray crystal structure determination.

引用

页码：260 / 267

页数：8

共 41 条

[1] OPTIMIZATION OF 2-DIMENSIONAL HOMONUCLEAR RELAYED COHERENCE TRANSFER NMR-SPECTROSCOPY [J].