THE 5'-TRIPHOSPHATES OF THE (-) AND (+) ENANTIOMERS OF CIS-5-FLUORO-1-[2-(HYDROXYMETHYL)-1,3-OXATHIOLANE-5-YL]CYTOSINE EQUALLY INHIBIT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE

被引：28

作者：

WILSON, JE ^{[1
]}

MARTIN, JL ^{[1
]}

BORROTOESODA, K ^{[1
]}

HOPKINS, S ^{[1
]}

PAINTER, G ^{[1
]}

LIOTTA, DC ^{[1
]}

FURMAN, PA ^{[1
]}

机构：

[1] EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 08期

关键词：

D O I：

10.1128/AAC.37.8.1720

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The (-) enantiomer of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine is a potent inhibitor of human immunodeficiency virus type 1 in vitro. The 5'-triphosphates of the (-) and (+) enantiomers equally inhibited the production of full-length minus-strand DNA in an endogenous reverse transcriptase reaction, each competitively inhibited DNA synthesis, and each was used as a chain-terminating substrate.

引用

页码：1720 / 1722

页数：3

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