IFN-GAMMA IS DIRECTLY CYTOSTATIC TO THE EXTRACELLULAR FORM (PROMASTIGOTE) OF LEISHMANIA-DONOVANI

被引：3

作者：

BHATTACHARYA, S ^{[1
]}

MANNA, PP ^{[1
]}

BANDYOPADHYAY, S ^{[1
]}

机构：

[1] INDIAN INST CHEM BIOL,4 RAJA SC MULLICK RD,CALCUTTA 700032,W BENGAL,INDIA

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1993年 / 37卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1993.tb01683.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the effect of various human cytokines on the in vitro growth of Leishmania donovani (L. donovani) promastigotes. rhIFN-alpha, rhIFN-beta, rhIL-1, rhIL-2, rhIL-3, rhIL-4, rhIL-6 and rhM-CSF had no effect. By contrast, rhIFN-gamma was directly growth inhibitory to L. donovani promastigotes in a dose-dependent manner. Anti-IFN-gamma antibody, but neither anti-IFN-alpha nor anti-IFN-beta antibody, abolished this promastigote growth inhibitory effect of rhIFN-gamma. L. donovani promastigotes were not lysed by rhIFN-gamma as determined by Cr-51-release assay. These data indicate that rhIFN-gamma is cytostatic, not cytotoxic, to L. donovani promastigotes.

引用

页码：680 / 683

页数：4

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