COMBINATIVE INTERACTIONS OF A HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) TAT ANTAGONIST WITH HIV REVERSE-TRANSCRIPTASE INHIBITORS AND AN HIV PROTEASE INHIBITOR

被引：9

作者：

CONNELL, EV

HSU, MC

RICHMAN, DD

机构：

[1] UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92093

[2] VET ADM MED CTR,SAN DIEGO,CA 92093

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 02期

关键词：

D O I：

10.1128/AAC.38.2.348

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Combinations of the human immunodeficiency virus (HIV) Tat protein antagonist Ro 24-7429 with either the HN protease inhibitor Ro 31-8959 or the HIV reverse transcriptase inhibitors AZT (3'-azido-3'-deoxythymidine), ddC (2', 3'-dideoxycytidine), ddI (2', 3'-dideoxyinosine), and nevirapine were synergistic or additive in reducing HN type 1 p24 antigen production in CEM cells or inhibiting HIV type 1-induced syncytium formation in HT4-6C cells.

引用

页码：348 / 352

页数：5

共 37 条

[1] RIBAVIRIN ANTAGONIZES INHIBITORY EFFECTS OF PYRIMIDINE 2',3'-DIDEOXYNUCLEOSIDES BUT ENHANCES INHIBITORY EFFECTS OF PURINE 2',3'-DIDEOXYNUCLEOSIDES ON REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS INVITRO [J].