REDUCED PLATELET CYTOCHROME-C-OXIDASE ACTIVITY IN ALZHEIMERS-DISEASE

被引：186

作者：

PARKER, WD

MAHR, NJ

FILLEY, CM

PARKS, JK

HUGHES, D

YOUNG, DA

CULLUM, CM

机构：

[1] UNIV COLORADO, SCH MED, DEPT NEUROL, DENVER, CO USA

[2] UNIV COLORADO, SCH MED, DEPT PEDIAT, DENVER, CO USA

[3] UNIV COLORADO, SCH MED, DEPT PREVENT MED & BIOMETR, DENVER, CO USA

[4] UNIV COLORADO, SCH MED, DEPT PSYCHIAT, DENVER, CO 80262 USA

来源：

NEUROLOGY | 1994年 / 44卷 / 06期

关键词：

D O I：

10.1212/WNL.44.6.1086

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec(-1)/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec(-1)/mg, p = 0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.

引用

页码：1086 / 1090

页数：5

共 38 条

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