INACTIVATED VIROSOME HEPATITIS-A VACCINE

被引：73

作者：

LOUTAN, L ^{[1
]}

BOVIER, P ^{[1
]}

ALTHAUS, B ^{[1
]}

GLUCK, R ^{[1
]}

机构：

[1] SWISS SERUM & VACCINE INST, DEPT MED & VIROL, BERN, SWITZERLAND

来源：

LANCET | 1994年 / 343卷 / 8893期

关键词：

D O I：

10.1016/S0140-6736(94)91162-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunopotentiating reconstituted influenza virosomes (IRIV) are efficient carrier systems for small virion particles such as hepatitis A virus (HAV). We evaluated immunogenicity and tolerability of an IRIV-HAV vaccine and the effectiveness of a booster by immunising 104 healthy HAV seronegative volunteers. A single dose was highly immunogenic, since 98% of volunteers had seroconverted after 2 weeks. Anti-HAV titres remained high, with 100% seroconversion rate 1 year later, when the booster was given. The vaccine was effective, with a 22-fold increase in geometric mean titres 1 month later. No serious adverse reactions were observed.

引用

页码：322 / 324

页数：3

共 12 条

[1]

AMBROSCH F, 1991, VIRAL HEPATITIS AND LIVER DISEASE, P98

[2]

ANDRE FE, 1990, PROG MED VIROL, V37, P72

[3] CLINICAL-ASSESSMENT OF THE SAFETY AND EFFICACY OF AN INACTIVATED HEPATITIS-A VACCINE - RATIONALE AND SUMMARY OF FINDINGS [J].

ANDRE, FE ;

DHONDT, E ;

DELEM, A ;

SAFARY, A .

VACCINE, 1992, 10 :S160-S168

[4] USE OF PRIOR VACCINATIONS FOR THE DEVELOPMENT OF NEW VACCINES [J].

ETLINGER, HM ;

GILLESSEN, D ;

LAHM, HW ;

MATILE, H ;

SCHONFELD, HJ ;

TRZECIAK, A .

SCIENCE, 1990, 249 (4967) :423-425

[5] IMMUNOPOTENTIATING RECONSTITUTED INFLUENZA-VIRUS VIROSOME VACCINE DELIVERY SYSTEM FOR IMMUNIZATION AGAINST HEPATITIS-A [J].

GLUCK, R ;

MISCHLER, R ;

BRANTSCHEN, S ;

JUST, M ;

ALTHAUS, B ;

CRYZ, SJ .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (06) :2491-2495

[6]

GLUCK R, 1993, 3RD C INT TRAV MED P

[7] ADJUVANTS - A BALANCE BETWEEN TOXICITY AND ADJUVANTICITY [J].

GUPTA, RK ;

RELYVELD, EH ;

LINDBLAD, EB ;

BIZZINI, B ;

BENEFRAIM, S ;

GUPTA, CK .

VACCINE, 1993, 11 (03) :293-306

[8] EPITOPE-SPECIFIC REGULATION .1. CARRIER-SPECIFIC INDUCTION OF SUPPRESSION FOR IGG ANTIHAPTEN ANTIBODY-RESPONSES [J].

HERZENBERG, LA ;

TOKUHISA, T .

JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (06) :1730-1740

[9] INADVERTENT ALUMINUM ADMINISTRATION DURING PLASMA-EXCHANGE DUE TO ALUMINUM CONTAMINATION OF ALBUMIN-REPLACEMENT SOLUTIONS [J].

MILLINER, DS ;

SHINABERGER, JH ;

SHUMAN, P ;

COBURN, JW .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (03) :165-167

[10]

POOVORAWAN Y, IN PRESS J INFECT DI

← 1 2 →