PREVENTION OF OCULAR INFLAMMATION-INDUCED BY LENS PROTEIN, ENDOTOXIN, AND INTERLEUKIN-1 WITH SYNTHETIC INTERLEUKIN-1 BLOCKERS

被引：25

作者：

CHIOU, GCY

YAO, QS

OKAWARA, T

机构：

[1] Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A&M University, College of Medicine, College Station, Texas

[2] Faculty of Pharmaceutical Science, Kumamoto University, Kumamoto

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1994年 / 10卷 / 03期

关键词：

D O I：

10.1089/jop.1994.10.577

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

It is well known that corticosteroids are potent anti-inflammatory agents, yet they produce serious side effects. Although arachidonate metabolite blockers have been developed for the treatment of inflammation, they are much less potent than corticosteroids. Furthermore, they still process serious side effects. In search of potent and safe non-steroidal anti-inflammatory agents (NSAIA), interleukin-1 (IL-1) blockers have been developed. Among 121 CK-analogs studied, CK-17, CK-1O1A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis. No serious side effects could be noticed with the doses of these compounds tested to date. These results indicate that the development of potent NSAIAs is feasible. Moreover, these compounds are not related to arachidonate metabolites.

引用

页码：577 / 586

页数：10

共 20 条

[1]

Chiou G.C.Y., Liu S.X.L., Novel non-arachidonate mediated, non-steroidal antiinflammatory agents, Curr. Drugs, (1994)

[2]

Chiou G.C.Y., Yao Q.S., Chang M.S., Okawara T., Treatment of ocular inflammation with a new class of non-steroidal anti-inflammatory agents, J. Ocular Pharmacol, (1994)

[3]

Dinarello C.A., Modalities for reducing interleukin-1 activity in disease, Trends in Pharmacol. Sci., 14, pp. 155-159, (1993)

[4]

Dawson M.M., Lymphokines and Interleukins, pp. 82-105, (1991)

[5]

Yamasaki T., Yashihara Y., Okamoto Y., Okawara T., Furukawa M., A new approach to the synthesis of pyridazino (4, 5,-c) pyridazinones, J. Heterocyclic Chem., 29, pp. 1313-1316, (1992)

[6]

Chiou G.C.Y., Chang M.S., Ocular inflammation induced by lens protein and its prevention with new agents, pp. 94-109, (1990)

[7]

Miyano K., Chiou G.C.Y., Pharmacological prevention of ocular inflammation induced by lens proteins, Ophth. Res., 16, pp. 256-263, (1984)

[8]

Chiou L.Y., Chiou G.C.Y., Ocular anti-inflammatory action of a lipoxygenase inhibitor in the rabbit, J. Ocular Pharmacol., 1, pp. 383-390, (1985)

[9]

Dziezyc J., Millichamp N.J., Rohde B.H., Baker J.S., Chiou G.C.Y., Effects of lipoxygenase inhibitors in a model of lens-induced uveitis in the dog, Amer. J. Vet. Res., 50, pp. 1877-1882, (1989)

[10]

Chang M.S., Chiou G.C.Y., Prevention of lens protein-induced ocular inflammation with cyclooxygenase and lipoxygenase inhibitors, J. Ocular Pharmacol., 5, pp. 353-360, (1989)

← 1 2 →