PLATINUM(II) COMPLEXES WITH PORPHYRIN LIGANDS - SYNTHESIS AND SYNERGISMS IN THE PHOTODYNAMIC TUMOR-THERAPY

被引：22

作者：

BRUNNER, H ^{[1
]}

OBERMEIER, H ^{[1
]}

SZEIMIES, RM ^{[1
]}

机构：

[1] UNIV REGENSBURG, DERMATOL KLIN & POLIKLIN, D-93053 REGENSBURG, GERMANY

来源：

CHEMISCHE BERICHTE-RECUEIL | 1995年 / 128卷 / 02期

关键词：

PORPHYRINS; PLATINUM(II) COMPLEXES; PHOTODYNAMIC THERAPY; ANTITUMOR ACTIVITY;

D O I：

10.1002/cber.19951280215

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Twelve porphyrin ligands (2-5, 8, 13-16, 19, 27, 28) and their platinum(II) complexes (29-40) were synthesized and characterized. Nine of the porphyrins are derived from hemin, and three are based on tetraphenylporphyrin. The Ligands were transformed into diammine-dicarboxylatoplatinum(II) complexes and diamine-dichloroplatinum(II) complexes. The antitumor activity in the photodynamic therapy of the Ligands and their complexes was tested in vitro towards the MDA-MB-231 mammary carcinoma cell line. The results obtained showed an additive effect of the photodynamic activity of the porphyrin skeleton when irradiated with visible red light and the cytotoxic activity of the platinum moiety in the complexes.

引用

页码：173 / 181

页数：9

共 28 条

[1] MESO-TETRA(HYDROXYPHENYL)PORPHYRINS, A NEW CLASS OF POTENT TUMOR PHOTOSENSITIZERS WITH FAVORABLE SELECTIVITY
BERENBAUM, MC
AKANDE, SL
BONNETT, R
KAUR, H
IOANNOU, S
WHITE, RD
WINFIELD, UJ
[J]. BRITISH JOURNAL OF CANCER, 1986, 54 (05) : 717 - 725
[2] BONNETT AJ, 1990, PHOTOCHEM PHOTOBIO B, V6, P309
[3] BRUNNER H, 1992, Z NATURFORSCH B, V47, P942
[4] SYNTHESIS AND ANTITUMOR-ACTIVITY OF PT(II) COMPLEXES OF ESTRADIOL DERIVATIVES
BRUNNER, H
SPERL, G
[J]. MONATSHEFTE FUR CHEMIE, 1993, 124 (01): : 83 - 102
[5] SYNTHESIS AND ANTITUMOR-ACTIVITY OF NEW PORPHYRIN-PLATINUM(II) COMPLEXES WITH THE CYTOSTATIC PLATINUM FRAGMENT ATTACHED TO THE PORPHYRIN SIDE-CHAINS
BRUNNER, H
MAITERTH, F
TREITTINGER, B
[J]. CHEMISCHE BERICHTE, 1994, 127 (11) : 2141 - 2149
[6] BRUNNER H, 1992, B SOC CHIM BELG, V101, P935
[7] BRUNNER H, IN PRESS ANGEW CHEM
[8] SUBSTITUTED DEUTEROPORPHYRINS .I. REACTIONS AT PERIPHERY OF PORPHYRIN RING
CAUGHEY, WS
ALBEN, JO
FUJIMOTO, WY
YORK, JL
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (08) : 2631 - &
[9] Dougherty T.J., 2007, ADV PHOTOCHEM, P275
[10] STUDIES ON THE STRUCTURE OF PORPHYRINS CONTAINED IN PHOTOFRIN-II
DOUGHERTY, TJ
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (05) : 569 - 573

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