RELAXANT AND BETA-2-ADRENOCEPTOR BLOCKING ACTIVITIES OF LABETALOL, DILEVALOL, AMOSULALOL AND KF-4317 ON THE RAT ISOLATED AORTA

被引：8

作者：

DOGGRELL, SA ^{[1
]}

机构：

[1] UNIV AUCKLAND, SCH MED, DEPT PHARMACOL, AUCKLAND, NEW ZEALAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1988年 / 40卷 / 11期

关键词：

D O I：

10.1111/j.2042-7158.1988.tb05180.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The KCl-contracted rat aorta is relaxed by labetalol, dilevalol, amosulalol and KF-4317. These relaxations are not reversed by ICI 118,551 at 10-6 M and, therefore, are not due to .beta.-adrenoceptor agonism. At 10-7 M, labetalol, dilevalol, amosulalol and KF-4317 were .beta.2-adrenoceptor antagonists as they inhibited the relaxant responses of rat aorta to procaterol.

引用

页码：812 / 815

页数：4

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