STUDIES ON INHIBITION OF GLUCOSE METABOLISM IN ISOLATED FAT CELLS BY BETA-ADRENERGIC BLOCKING AGENTS

被引:11
作者
ALLEN, DO
ASHMORE, J
机构
[1] Department of Pharmacology, Indiana University School of Medicine, Indianapolis
关键词
D O I
10.1016/0006-2952(69)90247-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of the l- and d-isomers of 1-(4-nitrophenyl)-l-hydroxy-2-isopropyl aminoethane and of propranolol on glucose and pyruvate metabolism were studied in isolated fat cells. At high concentration (10-3M) all three drugs reduced the incorporation of glucose-1-14C, and glucose-6-14C into 14CO2 and lipid-14C, both in the presence and absence of insulin. The incorporation of pyruvate-3-14C into 14CO2 and lipid-14C was also markedly reduced by these drugs. This effect of beta-adrenergic blocking agents appears to be independent of the blockade of the beta receptor. It is more likely the result of a general depression of cellular metabolism. © 1969.
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页码:1347 / &
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