PREPARATION OF STERICALLY STABILIZED NANOPARTICLES BY DESOLVATION FROM GRAFT-COPOLYMERS

被引:9
作者
ARTURSSON, P [1 ]
BROWN, L [1 ]
DIX, J [1 ]
GODDARD, P [1 ]
PETRAK, K [1 ]
机构
[1] CIBA GEIGY PHARMACEUT CORP,ADV DRUG DELIVERY RES UNIT,WIMBLEHURST RD,HORSHAM RH12 4AB,W SUSSEX,ENGLAND
关键词
D O I
10.1002/pola.1990.080281006
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A new method is described for the preparation of sterically stabilized nanoparticles of defined size and polydispersity which are stabilized in aqueous solution by the presence of covalently linked monomethoxy–poly (oxyethylene) (MeOPOE) chains. The nanoparticles (100–270 nm mean diameter) were prepared by a process of desolvation of a graft copolymer prepared from poly(2‐aminoethylmethacrylate) (PAEMA) and MeOPOE. Reproducible desolvation was achieved by the addition of sodium phosphate buffer to the copolymer in aqueous solution to give particles which were crosslinked in situ with the addition of glutaraldehyde. The size (mean diameter) and polydispersity (Q) of the particles were determined by Photon Correlation Spectroscopy (PCS). The temperature at which the desolvation reaction was performed was found to influence the particle size; at low temperatures (5–12°C), small particles were produced (99–121 nm, Q = 0.090–0.121), whereas at much higher temperatures (40–55°C), particles as large as 224–275 nm (Q = 0.138–0.127) were generated. Other parameters such as the graft copolymer concentration, the amount of glutaraldehyde added, the pH of the sodium phosphate buffer added, and the reaction time were found to be of relative insignificance in influencing the particle size. In addition to those involved in drug delivery, our method of nanoparticle preparation may be of interest to those engaged in the preparation of particulate materials and colloidal dispersions for other specific applications (e.g. stabilized photographic emulsions). Copyright © 1990 John Wiley & Sons, Inc.
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页码:2651 / 2663
页数:13
相关论文
共 13 条
[1]  
ARTURSSON P, UNPUB
[2]  
CANTOW MJR, 1967, POLYM FRACTIONATION
[3]  
Davis SS, 1986, SITE SPECIFIC DRUG D, P93
[4]   END GROUP-ANALYSIS OF COMMERCIAL POLY(ETHYLENE GLYCOL) MONOMETHYL ETHERS [J].
DEVOS, R ;
GOETHALS, EJ .
POLYMER BULLETIN, 1986, 15 (06) :547-549
[5]  
HOWES C, UNPUB
[7]   FUNCTIONALIZED POLYETHYLENE GLYCOLS AND POLYPEPTIDES IN ORGANIC-SYNTHESIS AND CATALYSIS [J].
MUTTER, M ;
ALTMANN, KH ;
GEHRHARDT, H .
REACTIVE POLYMERS, 1987, 6 (2-3) :99-107
[8]  
Napper D H., 1983, POLYM STABILIZATION, Vvol. 3
[9]  
OPPENHEIM RC, 1986, POLYM NANOPARTICLES, P1
[10]   EXPONENTIAL SAMPLING METHOD FOR LIGHT-SCATTERING POLYDISPERSITY ANALYSIS [J].
OSTROWSKY, N ;
SORNETTE, D ;
PARKER, P ;
PIKE, ER .
OPTICA ACTA, 1981, 28 (08) :1059-1070