PITUITARY MODULATION OF SULPIRIDE ACTION IN CENTRAL NERVOUS-SYSTEM OF RAT

被引：14

作者：

PORTALEONE, P

DICARLO, R

CRISPINO, A

GENAZZANI, E

机构：

[1] Institute of Pharmacology, University of Turin, Turin

来源：

NEUROSCIENCE LETTERS | 1978年 / 10卷 / 03期

关键词：

D O I：

10.1016/0304-3940(78)90244-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To verify whether the stimulation by sulpiride of hypothalamic adenylate cyclase was direct or mediated by release of pituitary hormones, the effect of sulpiride on female hypophysectomized rats was studied. In these animals sulpiride does not substantially modify hypothalamic adenylate cyclase, brain 3,4-dihydroxyphenylacetic acid (DOPAC) levels and serum prolactin concentrations. Chlorpromazine on the contrary inhibits hypothalamic adenylate cyclase activity and increases DOPAC levels both in intact and in hypophysectomized rats. As sulpiride hardly crosses the blood-brain barrier, its action on pituitary with prolactin release seems to be essential to start the neurochemical phenomena in the central nervous system. © 1978.

引用

页码：305 / 309

页数：5

共 16 条

[1] CATECHOLAMINE CONTROL OF GROWTH-HORMONE REGULATION - EVIDENCE FOR DISCRETE CHANGES IN DOPAMINE AND NORADRENALINE TURNOVER FOLLOWING GROWTH-HORMONE ADMINISTRATION [J].