GAS-CHROMATOGRAPHIC DETERMINATION OF GLIBENCLAMIDE IN PLASMA

被引：25

作者：

CASTOLDI, D ^{[1
]}

TOFANETTI, O ^{[1
]}

机构：

[1] BOEHRINGER BIOCHEM,RES LABS,VIA S UGUZZONE 5,I-20126 MILAN,ITALY

来源：

CLINICA CHIMICA ACTA | 1979年 / 93卷 / 02期

关键词：

D O I：

10.1016/0009-8981(79)90088-3

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

A gas-chromatographic method for glibenclamide determination in plasma is described. It involves derivatization of the drug with dinitrofluorobenzene and the use of an electron-capture detector. The quantitative evaluation is performed using tolbutamide as internal standard. Characteristics and specificity of the method for the principal metabolite of glibenclamide are examined. © 1979.

引用

页码：195 / 198

页数：4

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