THE RABBIT JUGULAR-VEIN IS A CONTRACTILE NK-1 RECEPTOR SYSTEM

被引：35

作者：

NANTEL, F ^{[1
]}

ROUISSI, N ^{[1
]}

RHALEB, NE ^{[1
]}

DION, S ^{[1
]}

DRAPEAU, G ^{[1
]}

REGOLI, D ^{[1
]}

机构：

[1] UNIV SHERBROOKE,SCH MED,DEPT PHARMACOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 179卷 / 03期

关键词：

(Rabbit); (Selectivity); Jugular vein; Neurokinin receptors; Substance P;

D O I：

10.1016/0014-2999(90)90189-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rabbit isolated jugular veins respond to substance P and related neurokinins with cononcentration-dependent contractions which appears to be due to the activation of a single neurokinin receptor of the NK-1 type. This is demonstrated by the order of potency of neurokinins and some of their fragments as well as by the strong activity of NK-1-selective agonists and the weakness of NK-2 and NK-3-selective agonists. The present indicate that the rabbit jugular vein provides a sensitive, specific and selective NK-1 preparation which responds directly to neurokinins with contractions and therefore can be useful for characterization of NK-1 agonists and antagonists. © 1990.

引用

页码：457 / 462

页数：6

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