MUSCLE AND NERVE CHANGES INDUCED BY PERHEXILINE-MALEATE IN MAN AND MICE

被引：48

作者：

FARDEAU, M

TOME, FMS

SIMON, P

机构：

[1] INSERM U 153, Paris

来源：

MUSCLE & NERVE | 1979年 / 2卷 / 01期

关键词：

D O I：

10.1002/mus.880020105

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Perhexiline maleate therapy may produce a polyneuropathy as well as other side effects in man. The Schwann‐cell origin of the neuropathy is demonstrated by morphologic studies. Ultrastructural studies of muscle and nerve biopsies showed the presence of intracytoplasmic inclusions, primarily in Schwann cells, muscle fibers, and endothelial cells. These inclusions were polymorphic and varied from one cell type to another. They were frequently associated with calcium deposits, and their structure suggested a lysosomal origin. It was possible experimentally to reproduce similar inclusions in mice. Furthermore, numerous tubular aggregates were observed in intoxicated mouse muscle fibers. Copyright © 1979 Houghton Mifflin Professional Publishers

引用

页码：24 / 36

页数：13

共 36 条

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