TUMOR-INHIBITING [1,2-BIS(FLUOROPHENYL)ETHYLENEDIAMINE]PLATINUM(II) COMPLEXES .3. EVALUATION OF THE MAMMARY-TUMOR INHIBITING PROPERTIES

被引：20

作者：

REILE, H

SPRUSS, T

MULLER, R

GUST, R

BERNHARDT, G

SCHONENBERGER, H

机构：

[1] Institut für Pharmazie, Universität Regensburg, Regensburg, D-8400, Sonderforschungsbereich 234

[2] Asta Pharma Ag, Frankfurt, D-6000

来源：

ARCHIV DER PHARMAZIE | 1990年 / 323卷 / 05期

关键词：

D O I：

10.1002/ardp.19903230509

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diastereomeric diaqua[1,2‐bis(4‐fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates produce a strong inhibition of the hormone‐dependent MXT‐M 3.2 mammary carcinoma of the B6D2F1 mouse. Besides an interference in the DNA synthesis in analogy to cisplatin a lowering of the estrogen level due to an interference in steroid biosynthesis is suggested as the mode of action. In contrast to the R,R/S,S configurated diaqua[1,2‐bis(4‐fluorophenyl)ethylenediamine]platinum(II) salts the corresponding R,S configurated compounds are also markedly active on the hormone‐independent MXT‐Ovex mammary carcinoma of the B6D2F1 mouse. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：301 / 306

页数：6

共 7 条

[1] BREAST TUMOR-CELL LINES FROM PLEURAL EFFUSIONS [J].