INVITRO AND INVIVO GENOTOXICITY EVALUATION OF HORMONAL DRUGS .1. HYDROCORTISONE

被引：21

作者：

BALI, D ^{[1
]}

SINGH, JR ^{[1
]}

SINGH, H ^{[1
]}

SANDHU, D ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Human Biol & Human Genet, Human Genet Lab, Amritsar 143005, Punjab, INDIA

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1990年 / 16卷 / 04期

关键词：

D O I：

10.1002/em.2850160406

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Genotoxic evaluation of a widely used glucocorticoid, hydrocortisone, was undertaken using a battery of in vitro and in vivo test systems. Human lymphocyte cultures and mouse bone marrow studies (micronuclei and sister chromatid exchange analyses) showed the drug to be very potent clastogen. However, the Ames/Salmonella assay both with and without S9 did not show an increase in the His+ revertants. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：250 / 254

页数：5

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