CLONIDINE REVERSES THE AMNESIA INDUCED BY DOPAMINE BETA HYDROXYLASE INHIBITION

被引:29
作者
FREEDMAN, LS
BACKMAN, MZ
QUARTERMAIN, D
机构
[1] Division of Behavioral Neurology, New York University School of Medicine, New York, NY 10010
关键词
Alpha-noradrenergic receptors; Amnesia; Clonidine; Diethyldithiocarbamate;
D O I
10.1016/0091-3057(79)90132-1
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The role of noradrenergic (NE) me mechanisms in amnesia induced by the dopamine-β-hydroxylase (DBH) inhibitor, diethyldithiocarbamate (DEDTC) was examined by studying the antiamnestic characteristics of the alpha-NE receptor stimulator clonidine. DEDTC (250 mg/kg) administered 3 hr prior to training to C57BL/6J mice resulted in marked deficits when retention of a multiple trial food motivated spatial discrimination task was measured 24 hr after learning. Investigation of the temporal aspects of recovery indicated that the agonist was an effective antiamnestic agent when administered 0, 1, 3, 21 and 23 hr after training. No recovery was observed when the drug was administered 6 and 18 hr posttraining. A dose response study of the effectiveness of clonidine administered 1 hr prior to testing indicated recovery of memory at doses ranging from 10-500 μg/kg. The clonidine induced recovery was not a result of general performance facilitation, but specific to the memory tested. In addition, the clonidine effect was pharmacologically specific to its actions on NE receptors, as recovery was blocked by pre-treatment with the alpha-NE antagonist, phentolamine. No recovery from DEDTC induced amnesia was seen with post-training or pre-test injection of d-amphetamine. © 1979.
引用
收藏
页码:259 / 263
页数:5
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