EFFECTS OF PANCURONIUM-BROMIDE ON CEREBRAL BLOOD-FLOW CHANGES DURING SEIZURES IN NEWBORN PIGS

被引:13
作者
POURCYROUS, M
LEFFLER, CW
BADA, HS
KORONES, SB
STIDHAM, GL
BUSIJA, DW
机构
[1] UNIV TENNESSEE CTR HLTH SCI,DEPT PEDIAT,RES NEONATAL PHYSIOL LAB,MEMPHIS,TN 38163
[2] UNIV TENNESSEE CTR HLTH SCI,DEPT OBSTET & GYNECOL,MEMPHIS,TN 38163
[3] UNIV TENNESSEE CTR HLTH SCI,DEPT PHYSIOL & BIOPHYS,MEMPHIS,TN 38163
关键词
D O I
10.1203/00006450-199206000-00019
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
We investigated the effects of pancuronium bromide pretreatment on cerebral blood flow (CBF) during bicuculline-induced seizures in anesthetized piglets. Arterial blood pressure, gases, pH, cerebral electrocortical activity, and CBF (radioactive microsphere) were monitored at baseline, 10 min after administration of pancuronium (0.3 mg/kg i.v.; n = 9) or vehicle (normal saline; n = 8), and again at 5, 15, and 60 min after bicuculline (3 mg/kg i.v.). No change in CBF from baseline was observed at 10 min after either saline or pancuronium treatment, before induction of seizures. In the saline group, CBF was 36 +/- 3 mL.min-1.100 g-1 before bicuculline and increased to 166 +/- 24 and 205 +/- 35 mL.min.1.100 g-1 at 5 and 15 min, respectively, after bicuculline, returning toward baseline by 60 min. In the pancuronium group at 5 min after bicuculline, CBF increased from 45 +/- 7 to 169 +/- 26 mL. min-1.100 g-1, but fell to 88 +/- 17 mL.min-1.100 g-1 at 15 min in contrast to saline-treated piglets. Also, at 15 min of seizures, differences between groups were observed in arterial blood pressure, gases, and pH. Although these variables were in the normal range with pancuronium treatment, the saline-treated animals had increased arterial blood pressure (81 +/- 6 mm Hg) and PCO2 (6 +/- 0.4 kPa) and decreased PO2 (7 +/- 0.5 kPa) and pH (6.91 +/- 0.06). Electrocortical activity was abnormal during seizures in both groups. At 60 min, reversal to normal activity was observed in six of nine pancuronium-treated animals versus two of eight saline-treated animals. These data suggest that pancuronium limits cerebral hyperemia during prolonged seizures by attenuating increases in blood pressure as a result of elimination of skeletal muscle activity. This leads to minimal alteration of arterial PCO2, Po2, and pH during seizures.
引用
收藏
页码:636 / 639
页数:4
相关论文
共 21 条
[1]   ROLE OF PROSTANOIDS IN CEREBROVASCULAR RESPONSES DURING SEIZURES IN PIGLETS [J].
BUSIJA, DW ;
LEFFLER, CW .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (01) :H120-H125
[2]   REGIONAL CEREBRAL BLOOD-FLOW DURING BICUCULLINE-INDUCED SEIZURES IN THE NEWBORN PIGLET - EFFECT OF PHENOBARBITAL [J].
CLOZEL, M ;
DAVAL, JL ;
MONIN, P ;
DUBRUC, C ;
MORSELLI, PL ;
VERT, P .
DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1985, 8 (03) :189-199
[3]   PREFERENTIAL BLOOD-FLOW TO BRAIN-STEM DURING GENERALIZED SEIZURES IN THE NEWBORN MARMOSET MONKEY [J].
FUJIKAWA, DG ;
DWYER, BE ;
WASTERLAIN, CG .
BRAIN RESEARCH, 1986, 397 (01) :61-72
[4]   CEREBRAL ENERGY METABOLISM, PH, AND BLOOD-FLOW DURING SEIZURES IN CAT [J].
HOWSE, DC ;
CARONNA, JJ ;
DUFFY, TE ;
PLUM, F .
AMERICAN JOURNAL OF PHYSIOLOGY, 1974, 227 (06) :1444-1451
[5]   SYMPATHETIC REGULATION OF CEREBRAL BLOOD-FLOW DURING SEIZURES IN NEWBORN LAMBS [J].
KURTH, CD ;
WAGERLE, LC ;
DELIVORIAPAPADOPOULOS, M .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (03) :H563-H568
[6]   PERIVASCULAR POTASSIUM AND PH AS DETERMINANTS OF LOCAL PIAL ARTERIAL DIAMETER IN CATS - MICROAPPLICATION STUDY [J].
KUSCHINSKY, W ;
THURAU, K ;
WAHL, M ;
BOSSE, O .
CIRCULATION RESEARCH, 1972, 31 (02) :240-+
[7]   CEREBRAL STIMULATION FOLLOWING SUCCINYLCHOLINE IN DOGS [J].
LANIER, WL ;
MILDE, JH ;
MICHENFELDER, JD .
ANESTHESIOLOGY, 1986, 64 (05) :551-559
[8]   CEREBRAL FUNCTION AND MUSCLE AFFERENT ACTIVITY FOLLOWING INTRAVENOUS SUCCINYLCHOLINE IN DOGS ANESTHETIZED WITH HALOTHANE - THE EFFECTS OF PRETREATMENT WITH A DEFASCICULATING DOSE OF PANCURONIUM [J].
LANIER, WL ;
IAIZZO, PA ;
MILDE, JH .
ANESTHESIOLOGY, 1989, 71 (01) :87-95
[9]  
LOU HC, 1979, ACTA PAEDIATR SCAND, V68, P803
[10]   ARTERIAL BLOOD-PRESSURE RESPONSE TO HEAVY RESISTANCE EXERCISE [J].
MACDOUGALL, JD ;
TUXEN, D ;
SALE, DG ;
MOROZ, JR ;
SUTTON, JR .
JOURNAL OF APPLIED PHYSIOLOGY, 1985, 58 (03) :785-790